Waterfront properties for sale in Big Pine Key are wonderful for Florida Keys real estate buyers who are looking for a relaxing enclave in one of the most beautiful spots in the Keys. The key is known for its natural beauty, and purchasing a Big Pine Key waterfront home for sale is the perfect way to take advantage of this appeal. This is the largest island in the Lower Florida Keys, with great neighborhoods including Punta Brisa, Long Beach Estates and more. Though the key is large in land area, it is not as densely populated as other areas, creating a secluded, tranquil atmosphere. Browse the Florida Keys MLS for all Big Pine Key waterfront home listings below.